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Metformin use significantly reduces risk of joint replacement in people with type 2 diabetes

A team of researchers from China, Taiwan and Australia aimed to determine whether metformin use was associated with a lower risk of total knee replacement (TKR) or total hip replacement (THR), as evidence to date has been sparse and inconclusive.

They analysed data from 69,706 participants who received a diagnosis of type 2 diabetes in Taiwan between 2000 and 2012 and compared the risk of TKR and/or THR between people taking metformin and those not taking metformin. The mean age was 63 years and half were women. About 90% of total joint replacements were related to osteoarthritis.

"We found that metformin use in patients with type 2 diabetes mellitus was associated with a significantly reduced risk of joint replacement, suggesting a potential therapeutic effect of metformin in patients with osteoarthritis," writes Dr. Changhai Ding, Clinical Research Center of Zhujiang Hospital, Southern Medical University, Guangzhou, China, with coauthors.

The authors call for randomised controlled trials to determine if metformin use is effective in patients with osteoarthritis.

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Upcoming Events

Hygiene and sustainability in endoscopy: finding the balance

Online Event
Thursday 22nd June 2023

EBME Expo 2023

Judds Lane, Coventry, England, GB, CV6 6
28th - 29th June 2023

AfPP Annual Conference 2023

University of York
10- 13 August 2023

MEDICA - Leading International Trade Fair

Schadowstraße 49, 40212 Düsseldorf, Germany
13- 16 November 2023

Future Surgery

Excel Centre London
14 - 15 November 2023

IPS IV Forum Annual Conference 2023

BCEC Birmingham
24th November 2023

Access the latest issue of Clinical Services Journal on your mobile device together with an archive of back issues.

Download the FREE Clinical Services Journal app from your device's App store

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