The website of the Clinical Services Journal

UK first as London hospital takes part in new clinical trial for brain cancer

The London Clinic, a private hospital and charity on London’s Harley Street, is the first and only UK hospital to participate in a landmark international phase 3 clinical trial of a treatment called intraoperative radiotherapy (IORT) for glioblastoma multiforme, a brain cancer with a high mortality rate.

Glioblastoma multiforme is among the cancers with the highest mortality rates because in most patients, the cancer comes back after treatment. Dame Tessa Jowell, the Labour politician, died last May from this type of brain cancer.

The London Clinic is one of 12 international hospitals taking part in the ‘INTRAGO 2’ phase 3 clinical trial. The international phase 3 clinical trial will look at the results of how IORT can help when after the brain tumour is removed, a high, focused dose of radiation is delivered directly to the tumour cavity to kill any microscopic cancer cells left behind.

The London Clinic the only UK hospital involved in the trial as it has invested in the Zeiss ‘Intrabeam’ IORT equipment – a mobile X-ray therapy unit which is not widely available in the NHS or at other private hospitals.

Professor Keyoumars Ashkan and Mr Ranj Bhangoo, both consultant neurosurgeons at the London Neurosurgery Partnership, and Dr Matt Williams, consultant oncologist, are leading The London Clinic’s participation in the clinical trial and are asking consultant oncologists and neurologists to put patients forward for the clinical trial. 

“This approach has been demonstrated to be effective with breast and colorectal cancers and we are optimistic that this new technique can help many people with this aggressive form of brain cancer. Intra-operative radiotherapy (IORT) is an innovative technique when a high dose of radiation is given at the same time as the surgical treatment to remove the brain tumour. In this way, the intra-operative radiation can essentially help sterilize the surgical cavity from residual tumour cells. In a way it helps to bridge the treatment gap between surgery and post-operative radiation,” said Prof Ashkan. 

“The Intrago 2 Phase 3 clinical trial allows the localised IORT 20-30Gy boost to be given in addition to standard care radiotherapy. The clinical trial is open to new patients with radiologically suspected glioblastoma or those with a previous biopsy or partial resection so long as further surgery to remove the tumour is clinically indicated and there has not been previous treatment with radiotherapy or chemotherapy. We therefore want consultant oncologists and neurologists to identify people who may be suitable candidates for this clinical trial and refer them early on,” said Mr Ranj Bhangoo. 

"The London Clinic is proud to be representing the UK in this international clinical trial. We already support our patients, consultants and clinical teams with a comprehensive neurological service. That includes high-spec linear accelerators for radiotherapy, stereotactic radiotherapy with CyberKnife, a state-of-the-art intensive care unit and a comprehensive rehabilitation and aftercare programme. Participation in this trial reflects our approach to research and innovation. It will offer some of our patients an additional, new treatment option,” saidMr Satya Bhattacharya, medical director of The London Clinic. 

Candidates must be aged 18 or older and younger than 80 and must not have had previous cranial radiotherapy. Clinicians who wish to put people forward for the clinical trial can contact +44(0)203 219 3315 or [email protected]

Upcoming Events

Future Surgery 2021

ExCel London
9th - 10th November 2021

Medica 2021

Dusseldorf Germany
15th - 18th November

Arab Health 2022

Dubai World Trade Centre
24th - 27th January

Central Sterilising Club 60th Anniversary Annual Scientific Meeting

Crowne Plaza, Bridge Foot, Stratford-upon-Avon, CV37 6YR
4th - 5th April

iM Med Decontamination Academy Spring Conference

Royal College of Physicians, London
11th May 2022

Access the latest issue of Clinical Services Journal on your mobile device together with an archive of back issues.

Download the FREE Clinical Services Journal app from your device's App store

Upcoming Events

Future Surgery 2021

ExCel London
9th - 10th November 2021

Medica 2021

Dusseldorf Germany
15th - 18th November

Arab Health 2022

Dubai World Trade Centre
24th - 27th January

Central Sterilising Club 60th Anniversary Annual Scientific Meeting

Crowne Plaza, Bridge Foot, Stratford-upon-Avon, CV37 6YR
4th - 5th April

iM Med Decontamination Academy Spring Conference

Royal College of Physicians, London
11th May 2022

Access the latest issue of Clinical Services Journal on your mobile device together with an archive of back issues.

Download the FREE Clinical Services Journal app from your device's App store

Step Communications Ltd, Step House, North Farm Road, Tunbridge Wells, Kent TN2 3DR
Tel: 01892 779999 Fax: 01892 616177
www.step-communications.com
© 2021 Step Communications Ltd. Registered in England. Registration Number 3893025